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Robert Naviaux Laboratory

Research in laboratory is divided in two groups: (1) Mitochondrial mechanisms of health and disease and healing, and (2) Ecogenetics, metabolomics, and environmental impacts on child health.  Areas of active research include the role of mitochondrial and metabolic reprogramming in healing and regeneration.  We are studying the role of the cell danger response (CDR) and ATP-related purinergic signaling on mitochondrial function in health and disease.  Our lab uses mass spectrometry, metabolomics, and exposomics as precision medicine tools to study several complex chronic disorders.  These include primary genetic forms of mitochondrial disease like Leigh syndrome and Alpers syndrome, autism spectrum disorder (ASD), major depressive disorder (MDD), Gulf War Illness (GWI), post-treatment Lyme disease syndrome (PTLDS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and the metabolic effects of exercise.  Pre-clinical studies in our lab have recently led to a small FDA-approved, randomized and placebo-controlled clinical trial to study the safety and efficacy of antipurinergic drug therapy as a new treatment for the core symptoms of autism spectrum disorder (ASD).

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Location: UC San Diego  Medical Center, CTF-C Building, 214 Dickenson Street, Room C-102
Mailing Address: 214 Dickinson St, CTF, C102, San Diego, CA 92103-8467
Phone Number: 619-543-2904

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